What is Hormone Pellet Replacement?
Schedule onlineHormone pellet replacement therapy involves placing an implant under your skin to deliver a slow, consistent level of synthetic bio-identical hormones. Bio-identical hormones are the most chemically identical hormones to the ones that our bodies produce naturally. This ensures optimal delivery of essential hormones, such as estradiol or testosterone, to patients who are suffering from the negative effects of natural hormone depletion.

Unlike other forms of hormone therapy, such as oral pills and transdermal creams or gels, pellet hormone replacement therapy aims to reduce the “up and down” effects of other types of supplemental hormones. Hormone pellet replacement therapy results in more consistent mood and energy levels. With a pellet hormone replacement therapy implant, individuals can maintain sustained hormone levels throughout the day for up to five months.
What are Hormone Pellets?
Specially formulated hormone pellet implants are very small and contain a natural source of bio-identical hormones. The pellets are placed in fatty tissue under the skin every three to four months, depending on the patient's natural physiological processes. The bio-identical hormones are slowly released from the pellets to closely mimic the release rate from the body. Placing the hormone pellets is a minimally-invasive procedure that is performed during an in-office visit. The pellets dissolve in your body, so they don’t need to be removed.
Benefits of Hormone Pellet Replacement Therapy
There are many benefits of receiving bio-identical hormone pellet replacement therapy: Increased muscle mass; Increased bone density; Improved strength; Better overall coordination; Enhanced physical performance Improved skin tone and hair texture; Better memory Increased concentration; Improved sexual health; Enhanced overall physical health.
Hormone Pellet Replacement Therapy for Men
Schedule onlineWhile men don’t experience menopause, they do experience a decrease in their hormone production through their later stages of life. This depletion of testosterone and other vital hormones is typically referred to as andropause or low T. Men generally experience a slight decrease in their hormone production by the age of 30 and may start seeing signs of andropause by the time they are 50 years old.

Signs of Andropause and Low Testosterone
Common signs of andropause or low testosterone include:
- Mood swings
- Loss of muscle mass
- Irritability
- Insomnia
- Low libido
- Erectile dysfunction
- Weight gain around the midsection.
How Hormone Pellet Replacement Therapy Helps Men
With the help of bio-identical hormone pellet replacement therapy, men may see an improvement in their physical health, as well as their mental well-being. This is due to the balancing and replenishment of hormones within the body. Men who start hormone replacement therapy may see improvement in their unwanted symptoms within just two weeks of treatment, with ultimate results becoming apparent within just six to eight weeks.
Hormone Pellet Replacement Therapy for Women
Schedule onlineWomen typically experience changes in their hormones throughout their lives, with the most significant changes occurring during puberty, pregnancy, and menopause. Women over the age of 50 typically start experiencing symptoms of menopause once their menstrual cycles end.

Signs of Menopause and Hormone Imbalances in Women
Common symptoms of menopause include:
- Chronic fatigue
- Hot flashes
- Insomnia
- Night sweats
- Weight gain around the midsection
- Mood swings.
How Bio-Identical Hormone Pellet Replacement Therapy Helps Women
Bio-identical hormone pellet replacement therapy may help ease the transition into menopause. By replenishing depleting hormones with a bio-identical supplement, women may see improvement in their menopause symptoms within just two to three weeks. In addition to improving their overall physical health, hormone replacement therapy may help with mental wellbeing by replacing lost melatonin, estrogen, and pregnenolone hormones.
Hormone Pellet Replacement and Weight Loss
Unwanted weight gain is one of the biggest challenges for men and women with menopause, andropause, and low testosterone levels.
Patients going through these next stages of life find that gaining weight is easier and losing it gets harder and harder every day. This is because the hormones in your body affect the speed of your metabolism. Therefore, lower levels of hormone production in certain patients may contribute to the onset of weight gain, despite living a healthy lifestyle that includes proper diet and exercise.
Patients who receive bio-identical hormone pellet replacement therapy treatments may lose weight during the course of treatment. While the increase in hormone levels may help increase metabolism and help patients lose weight, bio-identical hormone pellet replacement therapy is not considered a weight loss solution. It’s important that you always lead a healthy and active lifestyle while using hormone replacement therapy.
Hormone Pellet Replacement Therapy FAQs
Ask a question-
What can I expect from hormone pellet replacement therapy?
The first step for hormone pellet replacement therapy is to determine your current hormone levels via bloodwork. Based on the results, the medical provider determines the proper dosing and combination of hormones that your body needs for optimum performance. Hormone pellet implants are an ideal way to deliver hormones directly into the bloodstream 24/7 in a way that cannot be achieved with patches, pills, and other modes of delivery.
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When will I see results from hormone pellet replacement therapy?
Patients typically start seeing improvement in their menopause or andropause symptoms within two weeks of starting treatment. It's important to note that patients may not see the full effects of their bio-identical hormone pellet replacement therapy treatments for up to eight weeks following their pellet implant appointment. Follow up with your medical provider every four to six months to have your hormone levels checked and have your hormone replacement adjusted as needed.
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How much does hormone pellet replacement therapy cost?
The cost of hormone pellet replacement therapy varies greatly by individual. To guarantee the best results, it is recommended that you set up a consultation with a hormone replacement specialist to determine if hormone pellet replacement therapy is the best option for you, as well as the best combination of bio-identical hormone pellets.
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Am I a good candidate for hormone pellet replacement therapy?
If you are suffering from the negative effects of menopause, andropause, or low testosterone, hormone pellet therapy may be right for you. Ideal candidates for bio-identical hormone pellet therapy are in good general health and have realistic expectations of their potential results. Patients who do have pre-existing health conditions are encouraged to speak to a medical provider before starting hormone pellet replacement therapy.
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Is hormone pellet replacement therapy safe?
Yes, hormone pellet therapy is a completely safe and effective way to treat your unwanted side effects from menopause and low testosterone. Bio-identical hormone replacement therapy with pellets generally provides the best results for men and women because there are fewer unwanted side effects and fluctuations in hormone levels.
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How do I choose a provider for bio-identical hormone replacement therapy?
Look for a medical provider who has a long-standing reputation that demonstrates an expertise in bio-identical hormone replacement therapy and pellets. Take your time, and schedule consultations with a few providers until you find one that helps you feel comfortable and confident with the treatment.
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Patient testimonials
Read real reviews from the Anzolo community
Since May, I have been dealing with half a dozen skin cancer spots. Rick Brown and his assistants have done the examinations, biopsies, most final removals and hooked me up with Dr Valiga and Dr McIntire to remove a nasty spot on my ear and do that reconstruction. I’m happy to say that unless you knew, you wouldn’t notice where the cuts were. Plus, I never had to wait for an appointment and everyone at PD&CS were friendly and professional. Many thanks from me and I highly recommend Premier.
Paul Pringle on Paul Sabini, Dr via Google Reviews
Seriously disappointed with my appointment yesterday. I was OK with the 10 minute wait before they took me back but then I sat in a gown, in a chilly room, for 36 minutes. The nurse walked in. She said hi and then started talking to her assistant. She asked me to stand and I did, then she QUICKLY checked me over.
It was 7:26 PM when she walked in and it was 7:29 PM when she walked out. My entire body scan took less than 3 minutes. She missed my right arm, didn’t look at my ears or face, and never looked at my neck.
At the very least, she could've said “sorry to keep you waiting” or “we appreciate your patience” or anything to acknowledge that I’ve been sitting there that long. I just got a “hi.” And, could have, spent a minimum of 10 minutes really looking at my body.
Disappointing at best bc I have been a regular patient there for years. If you’re having a bad day, you don’t take it out on your patients.
So, when I went to the front desk, gave them my payment, and she said they want to see you back in a year and I said I won’t be back.
Patrick Murphy on Paul Sabini, Dr via Google Reviews
I had so many negative experiences with this practice, I don't know where to start. First, the only positive: their admin staff (call center and receptionists, especially the call center supervisor Jamie) were kind, responsive and generally helpful.
The clinical staff (PAs, Medical Records) could not have been less helpful. I have a hearing impairment and I use an assistive microphone. The first PA I saw, Alexa McSorley, whipped into the room and talked so fast that, even with my microphone, I could not understand her. After she whipped out of the room again, I left having no idea what she had said or recommended. So I went back and saw Stephanie Carlino. Her rate of speech was better, so I could understand her, but there were definitely no warm-and-fuzzies. I have a difficult-to-diagnose problem, and neither of them showed any curiosity about it. It felt like they were using a generic protocol, a checklist, rather than listening to me. I convinced Stephanie to do a biopsy of one of several areas on my body that have the problem. When it came back with no definitive diagnosis, her suggestions for treatment, such as they were, included a drug I had told her specifically and the practice in general that I am allergic to. So now, on top of feeling dismissed, I felt unsafe.
I decided to get a 2nd opinion elsewhere. But their Medical Records department only accepts Release of Information forms by fax. Who has a fax in their home??? I certainly don't. I ended up having the 2nd doctor's office fax my form over to them.
In the end, my experience in the 2nd doctor's office, Dermatology Partners in Hockessin, was the polar opposite of what I encountered at Premier Dermatology. It was a medical dermatology practice, so they weren't selling anything as the do at Premier. The office was small, the staff was courteous and personable, and the clinical staff (A DO and a PA) were outstanding. And they had ideas beyond giving me something I don't tolerate to resolve the issue.
If you have a problem that doesn't fall into a neat diagnostic category, definitely don't go to Premier Dermatology. Save yourself the stress, time, and money you would be wasting. There is something seriously wrong when a medical office's admin staff is kinder than its clinical staff.
Maria Quatrani on Paul Sabini, Dr via Google Reviews
My family and I have received excellent care here. Always takes the time to explain everything and made me feel completely at ease. Highly recommend.
Kathleen DeNight on Paul Sabini, Dr via Google Reviews